These findings should be useful to physicians and other health care providers as they counsel patients to take advantage of an important opportunity for disease prevention and health protection. Influenza vaccination of healthy working adults is not associated with higher rates of systemic symptoms when compared with placebo injection. In the multivariate model, vaccine again was not associated with systemic symptoms (OR, 0.9 95% CI, 0.7-1.2). You have higher protection a couple of weeks after receiving the shot, compared with four. After logistic regression, female sex (odds ratio, 1.5 95% confidence interval, 1.1-2.1), age younger than 40 years (OR, 1.6 95% CI, 1.2-2.2), and coincidental upper respiratory tract illness (OR, 4.6 95% CI, 3.2-6.6) were independently associated with higher rates of systemic symptoms. How long will its protection last Immunity against the flu tends to wane over the course of a season. Local reactions were mild in both groups and infrequently resulted in decreased use of the arm. No differences were seen between the 2 groups for the systemic symptoms of fever, myalgias, fatigue, malaise, or headaches. Millions of people in Germany received the jab, which authorities say saved many. Vaccine recipients reported a higher rate of arm soreness at the injection site than did placebo recipients (63.8% vs 24.1%, P <. The German biotech firm BioNTech is facing compensation claims for alleged side effects from its Comirnaty vaccine. Overall, 35.2% of placebo and 34.1% of vaccine recipients reported at least 1 of these systemic symptoms (P =. No differences were seen between the 2 groups for the systemic symptoms of fever, myalgias, fatigue, malaise, or headaches. Soreness, redness, and/or swelling at the injection site Headache Fever Nausea Muscle aches The symptoms listed above should resolve in a few days. Baseline characteristics were similar between the groups, and 99% of subjects completed interviews to assess side effects after the study injection. Of 849 subjects enrolled in the study, 425 received a placebo and 424 received influenza vaccine. ![]() Local and systemic symptoms during the week following the injection were evaluated through structured telephone interviews. Healthy working adults were recruited during October and November 1994 and were randomized to receive influenza vaccine or placebo injections. Taking pain relievers can help ease your discomfort. ![]() This also usually happens on the first day and goes away within two days. This randomized, double-blind, placebo-controlled trial assessed side effects following vaccination among healthy working adults. After your shot, you might have headaches or some achiness and pain in the muscles throughout your body. Concern about side effects is a barrier to influenza vaccination.
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